Search on:
CALCIUM-DEPENDENT NEUTRAL PROTEINASE
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Calpain
Descriptor
Spanish
:
Calpaína
Descriptor
Portuguese
:
Calpaína
Synonyms
English
:
Calcium-Activated Neutral Protease
Calcium-Dependent Neutral Proteinase
Tree Number:
D08.811.277.656.262.500.120
D08.811.277.656.300.200.120
Definition
English
:
Cysteine
proteinase found in many
tissues
. Hydrolyzes a variety of endogenous
proteins
including
NEUROPEPTIDES
;
CYTOSKELETAL PROTEINS
;
proteins
from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and
erythrocytes
. Two subclasses having high and low
calcium
sensitivity are known. Removes Z-discs and M-lines from
myofibrils
. Activates
phosphorylase kinase
and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Indexing Annotation
English
:
/biosyn /physiol permitted
History Note
English
:
86
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23227
Unique Identifier:
D002154
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS